October 27, 2023
Argonne Office in DC
America/New_York timezone


Thursday, October 26th (OPTIONAL)

7:00 pm - Kirwan's on the Wharf (Reservation under Kim Phan Lisa Hundley)

                 749 Wharf Street Southwest, Washington, DC 20024, +1 202-554-3818


Friday, October 27th

Draft Agenda (final agenda will be sent ahead of the meeting) 


08:00-08:15 Coffee and Light refreshments 


08:15 – 08:30 Welcome Remarks 

  • LLNL and ANL  

  • BARDA  

  • Introductions 


08:30 – 09:00 National needs and perspective 

·      Public Health perspective – Dr. Ashish Jha (Dean of Public Health, Brown University)  

09:00 –10:00 Keynote & Discussion 

  • Interpreting the evolution of SARS-CoV-2 Prof. Jesse Bloom, University of Washington 

  • Challenges and opportunities for predicting viral adaptation  

10:00-10:15 Break 


10:15-12:00 Advanced computational approaches for predicting viral adaptation 

·       Whole Genome Foundation Models for Predicting Viral Evolution – Arvind Ramanathan, ANL  

·       Structure-based and protein language models for function prediction – Jonathan Allen, LLNL  

·       Predicting evolution of SARS-CoV-2 and Influenza– Prof. John Barton, University of Pittsburgh 

·       Discussion    


12:00-01:00 Lunch (on-site) 


01:00-02:15 Advanced experimental approaches to study virus adaptation 

·        Pseudovirus deep mutational scanning to map phenotypes that shape viral evolution, Prof. Jesse Bloom, University of Washington 

·        Expanding human broadly neutralizing antibodies using rationally designed vaccine – lessons from Influenza Prof. Daniel Lingwood,  The Ragon Institute of MGH, MIT and Harvard 

·       Platforms for development of universal viral countermeasures, and approaches to measuring viral fitness related to emergence potential Prof. Gary Kobinger, University of Texas Medical Branch/Galveston National Laboratory and Professor Scott Weaver.

·       Discussion 


02:15-03:00 Summary discussion 


03:00 Adjourn