Thursday, October 26th (OPTIONAL)
7:00 pm - Kirwan's on the Wharf (Reservation under Kim Phan Lisa Hundley)
749 Wharf Street Southwest, Washington, DC 20024, +1 202-554-3818
Friday, October 27th
Draft Agenda (final agenda will be sent ahead of the meeting)
08:00-08:15 Coffee and Light refreshments
08:15 – 08:30 Welcome Remarks
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LLNL and ANL
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BARDA
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Introductions
08:30 – 09:00 National needs and perspective
· Public Health perspective – Dr. Ashish Jha (Dean of Public Health, Brown University)
09:00 –10:00 Keynote & Discussion
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Interpreting the evolution of SARS-CoV-2 Prof. Jesse Bloom, University of Washington
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Challenges and opportunities for predicting viral adaptation
10:00-10:15 Break
10:15-12:00 Advanced computational approaches for predicting viral adaptation
· Whole Genome Foundation Models for Predicting Viral Evolution – Arvind Ramanathan, ANL
· Structure-based and protein language models for function prediction – Jonathan Allen, LLNL
· Predicting evolution of SARS-CoV-2 and Influenza– Prof. John Barton, University of Pittsburgh
· Discussion
12:00-01:00 Lunch (on-site)
01:00-02:15 Advanced experimental approaches to study virus adaptation
· Pseudovirus deep mutational scanning to map phenotypes that shape viral evolution, Prof. Jesse Bloom, University of Washington
· Expanding human broadly neutralizing antibodies using rationally designed vaccine – lessons from Influenza Prof. Daniel Lingwood, The Ragon Institute of MGH, MIT and Harvard
· Platforms for development of universal viral countermeasures, and approaches to measuring viral fitness related to emergence potential Prof. Gary Kobinger, University of Texas Medical Branch/Galveston National Laboratory and Professor Scott Weaver.
· Discussion
02:15-03:00 Summary discussion
03:00 Adjourn
